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慢性肉芽肿病患者多形核白细胞中的花生四烯酸代谢

Arachidonic acid metabolism in polymorphonuclear leukocytes from patients with chronic granulomatous disease.

作者信息

Smith D M, Walsh C E, Dechatelet L R, Waite M

出版信息

Infect Immun. 1983 Jun;40(3):1230-3. doi: 10.1128/iai.40.3.1230-1233.1983.

DOI:10.1128/iai.40.3.1230-1233.1983
PMID:6406364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC348183/
Abstract

The effect of the calcium ionophore A23187 on the release and metabolism of [3H]arachidonic acid was examined in normal polymorphonuclear leukocytes and those obtained from patients with chronic granulomatous disease. The ionophore A23187 which stimulates oxidative metabolism in normal polymorphonuclear leukocytes was ineffective in increasing oxidative metabolism (chemiluminescence) in polymorphonuclear leukocytes from patients with chronic granulomatous disease. However, the ionophore A23187 stimulated the release of [3H]arachidonic acid from chronic granulomatous disease neutrophil phospholipids and stimulated its metabolism into hydroxyeicosatetraenoic acids and leukotrienes.

摘要

在正常多形核白细胞以及从慢性肉芽肿病患者体内获取的多形核白细胞中，研究了钙离子载体A23187对[3H]花生四烯酸释放和代谢的影响。钙离子载体A23187可刺激正常多形核白细胞的氧化代谢，但对增加慢性肉芽肿病患者多形核白细胞的氧化代谢（化学发光）无效。然而，钙离子载体A23187可刺激慢性肉芽肿病中性粒细胞磷脂释放[3H]花生四烯酸，并刺激其代谢生成羟基二十碳四烯酸和白三烯。

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本文引用的文献

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The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid.凝血酶对血小板的初始作用。在花生四烯酸产生之前，磷脂酰肌醇转化为磷脂酸。
J Biol Chem. 1981 May 25;256(10):5037-40.

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