Derry J E, McLean W M, Freeman J B
JPEN J Parenter Enteral Nutr. 1983 Mar-Apr;7(2):131-5. doi: 10.1177/0148607183007002131.
The systemic absorption from topical applications of 40% zinc oxide ointment was investigated in a series of healthy subjects (phase one) and in patients receiving total parenteral nutrition (phase two). In the first phase, six subjects completed a controlled, cross-over trial involving 3 hourly serum sample determinations for zinc concentration following a massive application of 40% zinc oxide ointment and plain petrolatum ointment. There was a mean increase in serum zinc from 107.3 +/- 5.32 to 116.1 +/- 5.02 micrograms/dL 1 hr after application of 40% zinc oxide ointment (p greater than 0.05). Three patients receiving total parenteral nutrition completed phase two of the protocol in which 40% zinc oxide ointment was applied daily to a specified area of the thigh. Analysis of these patients' serum revealed that the zinc concentrations remained relatively constant over the 10-day study period. These findings suggest that topical applications of 40% zinc oxide ointment do not result in significant absorption. This study serves as a starting point for further investigations.
在一系列健康受试者（第一阶段）和接受全胃肠外营养的患者（第二阶段）中，研究了40%氧化锌软膏局部应用后的全身吸收情况。在第一阶段，6名受试者完成了一项对照交叉试验，在大量涂抹40%氧化锌软膏和平凡凡士林软膏后，每3小时测定一次血清锌浓度。涂抹40%氧化锌软膏1小时后，血清锌平均从107.3±5.32微克/分升增加到116.1±5.02微克/分升（p>0.05）。3名接受全胃肠外营养的患者完成了方案的第二阶段，其中每天在大腿特定区域涂抹40%氧化锌软膏。对这些患者血清的分析显示，在为期10天的研究期间，锌浓度保持相对稳定。这些发现表明，局部应用40%氧化锌软膏不会导致显著吸收。本研究作为进一步研究的起点。
