人类载脂蛋白A1的基因结构
Gene structure of human apolipoprotein A1.
作者信息
Shoulders C C, Kornblihtt A R, Munro B S, Baralle F E
出版信息
Nucleic Acids Res. 1983 May 11;11(9):2827-37. doi: 10.1093/nar/11.9.2827.
Abstract
Apolipoprotein A1 is the major polypeptide of the human plasma high density lipoprotein (HDL). The structure and function of the apo A1 gene are of interest because of the inverse correlation shown between HDL levels and coronary heart disease. We have determined the nucleotide sequence of the apo A1 gene previously isolated. Its coding sequence is interrupted by two introns of 185 and 588 base pairs. As there may be one or more introns in the 5' non coding region, the 5' end of the gene could not be precisely located. The human apo A1 has an unusual propeptide segment very similar to its rat counterpart. The data reported here provide an essential basis for future studies of structural and functional alleles of the apo A1 gene.
摘要
载脂蛋白A1是人类血浆高密度脂蛋白（HDL）的主要多肽。由于HDL水平与冠心病之间存在负相关，载脂蛋白A1基因的结构和功能备受关注。我们已经确定了先前分离的载脂蛋白A1基因的核苷酸序列。其编码序列被两个分别为185和588个碱基对的内含子中断。由于5'非编码区可能存在一个或多个内含子，因此该基因的5'端无法精确定位。人类载脂蛋白A1有一个与其大鼠对应物非常相似的异常前肽段。本文报道的数据为载脂蛋白A1基因的结构和功能等位基因的未来研究提供了重要依据。
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