Meijlink F C, van het Schip A D, Arnberg A C, Wieringa B, Ab G, Gruber M
J Biol Chem. 1981 Sep 25;256(18):9668-71.
We describe two cloned genomic DNA fragments, both bearing the entire apo very low density lipoprotein II gene. Electron microscopy and restriction enzyme mapping showed that this gene is split into at least four coding sequences by three or more intervening sequences. A very short exon at the 5'-end of the gene is separated by a 1.5-kilobase intron from the second exon, which codes for the AUG initiation codon of the mRNA.
我们描述了两个克隆的基因组DNA片段，它们都带有完整的载脂蛋白极低密度脂蛋白II基因。电子显微镜和限制性酶切图谱显示，该基因被三个或更多的间隔序列分割成至少四个编码序列。基因5'端的一个非常短的外显子被一个1.5千碱基的内含子与第二个外显子隔开，第二个外显子编码mRNA的AUG起始密码子。
