碳酸锂对大鼠血小板中血清素摄取的影响。

Effects of lithium carbonate on serotonin uptake in rat blood platelets.

Arora R C, Fessler R G, Meltzer H Y

Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(1):39-45. doi: 10.1016/0278-5846(83)90087-8.

Abstract

Lithium carbonate administration to male rats for 1 to 4 weeks increased the affinity of platelet serotonin (5-HT) uptake (decreased Km) and decreased the rate of 5-HT uptake (Vmax) when the serum lithium levels were 0.5 meq/1 to 0.65 meq/l. When the serum levels were increased further to 1 meq/1, Vmax decreased further, without additional change in Km. 2. No effect on the kinetics of 5-HT uptake was observed when serum lithium levels were at 0.4 meq/1 or below. 3. Addition of lithium carbonate in vitro (1 meq/1) had no effect on the Km and Vmax of rat platelet 5-HT uptake. 4. The possible mechanism of the inhibitory effect of lithium treatment on platelet 5-HT uptake is discussed.

摘要

当血清锂水平为0.5毫当量/升至0.65毫当量/升时，对雄性大鼠给予碳酸锂1至4周，可增加血小板5-羟色胺（5-HT）摄取的亲和力（降低米氏常数），并降低5-HT摄取速率（最大反应速度）。当血清水平进一步升至1毫当量/升时，最大反应速度进一步降低，而米氏常数无额外变化。2. 当血清锂水平为0.4毫当量/升或更低时，未观察到对5-HT摄取动力学的影响。3. 在体外添加碳酸锂（1毫当量/升）对大鼠血小板5-HT摄取的米氏常数和最大反应速度无影响。4. 讨论了锂治疗对血小板5-HT摄取抑制作用的可能机制。