环孢素A抑制人胸腺细胞和T淋巴细胞合成γ干扰素。
Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporin A.
作者信息
Reem G H, Cook L A, Vilcek J
出版信息
Science. 1983 Jul 1;221(4605):63-5. doi: 10.1126/science.6407112.
PMID:6407112
Abstract
Cyclosporin A depresses the synthesis of gamma interferon by human thymocytes and T lymphocytes in vitro. This observation is of potential clinical significance because the long-term treatment of transplant patients with cyclosporin A, a widely used immunosuppressive agent, can give rise to B-cell lymphoma resulting from Epstein-Barr virus activation.
摘要
环孢菌素A在体外可抑制人胸腺细胞和T淋巴细胞合成γ干扰素。这一观察结果具有潜在的临床意义，因为广泛使用的免疫抑制剂环孢菌素A对移植患者进行长期治疗可能会因爱泼斯坦-巴尔病毒激活而引发B细胞淋巴瘤。
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