环孢素A抑制人胸腺细胞和T淋巴细胞合成γ干扰素。

Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporin A.

作者信息

Reem G H, Cook L A, Vilcek J

出版信息

Science. 1983 Jul 1;221(4605):63-5. doi: 10.1126/science.6407112.

Abstract

Cyclosporin A depresses the synthesis of gamma interferon by human thymocytes and T lymphocytes in vitro. This observation is of potential clinical significance because the long-term treatment of transplant patients with cyclosporin A, a widely used immunosuppressive agent, can give rise to B-cell lymphoma resulting from Epstein-Barr virus activation.

摘要

环孢菌素A在体外可抑制人胸腺细胞和T淋巴细胞合成γ干扰素。这一观察结果具有潜在的临床意义，因为广泛使用的免疫抑制剂环孢菌素A对移植患者进行长期治疗可能会因爱泼斯坦-巴尔病毒激活而引发B细胞淋巴瘤。