Alm P, Brandt L, Olsson H
Virchows Arch A Pathol Anat Histopathol. 1983;399(3):355-60. doi: 10.1007/BF00612953.
A breast tumour from a 65-year old woman was found to be a primary non-Hodgkin lymphoma, a very rare primary malignancy in this location. The lymphoma was of a diffuse histiocytic type according to the classification of Rappaport, or polymorphic immunocytoma according to the Kiel classification. Immunohistochemistry, not previously reported for breast lymphomas, revealed the production of IgA. In the serum this appeared as an IgA M-component which was greatly reduced after tumour removal. Immunological properties of primary breast lymphomas are reviewed, we suggest further extended studies with the immunohistochemical use of marker substances for the evaluation of prognosis.
一名65岁女性的乳腺肿瘤被发现是原发性非霍奇金淋巴瘤，这在该部位是一种非常罕见的原发性恶性肿瘤。根据Rappaport分类，该淋巴瘤为弥漫性组织细胞型，或根据Kiel分类为多形性免疫细胞瘤。免疫组化（此前未报道过乳腺淋巴瘤的免疫组化情况）显示有IgA产生。在血清中，这表现为一种IgA M成分，肿瘤切除后其水平大幅降低。本文对原发性乳腺淋巴瘤的免疫学特性进行了综述，我们建议进一步扩大研究，采用免疫组化方法使用标记物质来评估预后。
