外科患者的念珠菌感染
Candida infections in surgical patients.
作者信息
Marsh P K, Tally F P, Kellum J, Callow A, Gorbach S L
出版信息
Ann Surg. 1983 Jul;198(1):42-7. doi: 10.1097/00000658-198307000-00008.
Abstract
Serious Candida infections were seen in 55 surgical patients from January 1977 through December 1980. Most of the patients had compromising underlying conditions and many were elderly. Broad-spectrum antibiotics and total parenteral nutrition (TPN) appeared to predispose patients to Candida infections. Mortality rate from Candida was 38%. A high percentage of patients with positive blood or bile cultures died as a result of Candida infection. Therapy with intravenous amphotericin B was highly effective if given in adequate dosage. No patient receiving more than 200 mg of amphotericin B died, but the mortality rate was 56% in those receiving lower doses.
摘要
1977年1月至1980年12月期间，55名外科手术患者出现了严重的念珠菌感染。大多数患者有基础疾病，且很多患者年事已高。广谱抗生素和全胃肠外营养（TPN）似乎使患者易患念珠菌感染。念珠菌感染导致的死亡率为38%。血培养或胆汁培养呈阳性的患者中，很大比例因念珠菌感染死亡。静脉注射两性霉素B治疗，若给予足够剂量则疗效显著。接受超过200毫克两性霉素B治疗的患者无一死亡，但接受较低剂量治疗的患者死亡率为56%。
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