一项比较氟伏沙明和丙咪嗪的双盲对照临床试验。
A double-blind controlled clinical trial comparing fluvoxamine with imipramine.
作者信息
Guelfi J D, Dreyfus J F, Pichot P
出版信息
Br J Clin Pharmacol. 1983;15 Suppl 3(Suppl 3):411S-417S. doi: 10.1111/j.1365-2125.1983.tb02131.x.
Abstract
1 The effects of fluvoxamine to a maximum of 300 mg daily were compared with those of imipramine to a maximum of 200 mg daily, in 151 patients with primary major depression. 2 Four weeks of treatment with fluvoxamine resulted in 67.2% improvement (+/- s.d. 21.6) on the Hamilton Rating Scale for Depression (26 items). Treatment with imipramine showed 62.1% improvement (+/- s.d. 29.5) on this scale. 3 Fluvoxamine had no untoward effects on the cardiovascular system, while imipramine produced systematic increases in the postural fall in blood pressure. Dry mouth, nausea, daytime somnolence and tremor were seen with fluvoxamine treatment, while imipramine was associated with dry mouth, daytime somnolence, dizziness and tremor. 4 We conclude that fluvoxamine seems to have the same general antidepressant efficacy as imipramine. It was not associated with any safety problems and was generally well tolerated.
摘要
- 在151例原发性重度抑郁症患者中，比较了每日最大剂量达300毫克的氟伏沙明与每日最大剂量达200毫克的丙咪嗪的疗效。2. 用氟伏沙明治疗四周后，汉密尔顿抑郁量表（26项）显示改善率为67.2%（±标准差21.6）。用丙咪嗪治疗在该量表上显示的改善率为62.1%（±标准差29.5）。3. 氟伏沙明对心血管系统无不良影响，而丙咪嗪会使体位性血压下降系统性增加。氟伏沙明治疗出现口干、恶心、日间嗜睡和震颤，而丙咪嗪与口干、日间嗜睡、头晕和震颤有关。4. 我们得出结论，氟伏沙明似乎具有与丙咪嗪相同的一般抗抑郁疗效。它未出现任何安全问题，总体耐受性良好。
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