McCulloch E A
Blood. 1983 Jul;62(1):1-13.
This paper deals with three themes: (1) the nature of differentiation in normal and leukemic processes, (2) stochastic and deterministic control mechanisms that affect differentiation, and (3) the nature of the events that separate self-renewing stem cells from their committed descendants. These all impinge on both myelopoietic and lymphopoietic leukemias. The view is advanced that differentiation continues in these diseases, but new programs are assembled abnormally but with normal components.
（1）正常和白血病过程中的分化本质；（2）影响分化的随机和确定性控制机制；（3）将自我更新干细胞与其定向后代区分开来的事件的本质。这些主题均与骨髓性和淋巴细胞性白血病相关。本文提出的观点是，在这些疾病中分化仍在继续，但新的程序是以正常成分异常组装而成。
