Till J E, Mak T W, Price G B, Senn J S, McCulloch E A
Hamatol Bluttransfus. 1976;19:33-45. doi: 10.1007/978-3-642-87524-3_4.
Cellular organization and communication in leukemic hemopoiesis may be compared with its counterpart in normal hemopoiesis. Results obtained using cell culture methods have provided some support for the view that leukemic hemopoiesis, like normla hemopoiesis, may involve 3 levels of differentiation: leukemic stem cells, committed leukemic progenitors, and more mature cells. Evidence is also beginning to emerge that leukemic populations may be regulated by messages from the environment in a manner analogous to normal hemopoiesis. The apparent similarities between leukemic and normal hemopoiesis raise, the possibility that the target cell for leukemic transformation is the normal pluripotent stem cell. The development of culture methods for the production of leukovirus-like particles from human leukemic cells provides a possible first step toward the direct identification of leukemic target cells.
白血病造血过程中的细胞组织和通讯可与其正常造血过程中的对应情况相比较。使用细胞培养方法获得的结果为以下观点提供了一些支持，即白血病造血与正常造血一样，可能涉及三个分化水平：白血病干细胞、定向白血病祖细胞和更成熟的细胞。也开始有证据表明，白血病细胞群可能以类似于正常造血的方式受到来自环境的信息调节。白血病造血与正常造血之间明显的相似性增加了白血病转化的靶细胞是正常多能干细胞的可能性。从人白血病细胞生产白血病病毒样颗粒的培养方法的发展为直接鉴定白血病靶细胞提供了可能的第一步。
