口服奥美拉唑的最佳剂量，以实现胃内酸度最大程度的24小时降低。
Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity.
作者信息
Sharma B K, Walt R P, Pounder R E, Gomes M D, Wood E C, Logan L H
出版信息
Gut. 1984 Sep;25(9):957-64. doi: 10.1136/gut.25.9.957.
Abstract
In a series of 59 experiments in nine duodenal ulcer patients, 24 hour intragastric acidity was measured before, during, and after treatment with daily oral omeprazole. Omeprazole 10, 20, and 30 mg/day for one week caused a 37, 90, and 97% decrease of 24 hour intragastric acidity, respectively. No further decrease of acidity was observed when the dose of omeprazole was doubled to 60 mg/day, or after a second week of treatment with 30 mg/day. One week after stopping treatment with omeprazole (14 doses) there was a significant 26% decrease of 24 hour intragastric acidity, with full recovery seven weeks later. Fasting plasma gastrin concentration was significantly raised during treatment with all doses of omeprazole. Omeprazole 30 mg/day is the optimal dose for a maximal decrease of 24 hour intragastric acidity in duodenal ulcer patients.
摘要
在对9名十二指肠溃疡患者进行的59项实验中，在每日口服奥美拉唑治疗前、治疗期间及治疗后测量了24小时胃内酸度。奥美拉唑10毫克/天、20毫克/天和30毫克/天治疗一周后，24小时胃内酸度分别下降了37%、90%和97%。当奥美拉唑剂量加倍至60毫克/天或用30毫克/天治疗第二周后，未观察到酸度进一步下降。停止使用奥美拉唑（14剂）治疗一周后，24小时胃内酸度显著下降26%，7周后完全恢复。在使用所有剂量的奥美拉唑治疗期间，空腹血浆胃泌素浓度显著升高。对于十二指肠溃疡患者，30毫克/天的奥美拉唑是使24小时胃内酸度最大程度降低的最佳剂量。
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