魔鬼爪（钩果草）：无证据表明其在治疗关节炎疾病方面具有抗炎活性。
Devil's Claw (Harpagophytum procumbens): no evidence for anti-inflammatory activity in the treatment of arthritic disease.
作者信息
Whitehouse L W, Znamirowska M, Paul C J
出版信息
Can Med Assoc J. 1983 Aug 1;129(3):249-51.
Abstract
Devil's Claw (Harpagophytum procumbens), an herbal product being marketed in Canada as a home remedy for the relief of arthritic disease, was screened for efficacy with standard preclinical screening methods. At doses 100 times or greater than the recommended daily dose for humans, Devil's Claw was completely ineffective in reducing edema of the rat hind foot induced by either lambda-carrageenan or Mycobacterium butyricum. At concentrations of up to 1 x 10(5) microgram/ml, Devil's Claw was also ineffective as an in-vitro inhibitor of prostaglandin synthetase. These results indicate that Devil's Claw lacks the anti-inflammatory properties possessed by all antiarthritic drugs of the nonsteroidal, anti-inflammatory analgesic type.
摘要
魔鬼爪（哈帕戈菲图姆匍匐草）是一种在加拿大作为缓解关节炎疾病的家庭疗法销售的草药产品，已采用标准临床前筛选方法对其疗效进行了筛选。在剂量为人类推荐日剂量的100倍或更高时，魔鬼爪对于减轻由λ-角叉菜胶或丁酸分枝杆菌引起的大鼠后足水肿完全无效。在浓度高达1×10⁵微克/毫升时，魔鬼爪作为前列腺素合成酶的体外抑制剂也无效。这些结果表明，魔鬼爪缺乏所有非甾体抗炎镇痛类抗关节炎药物所具有的抗炎特性。
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