Sugg U, Frösner G G, Lissner R, Stunkat R, Schneider W
Eur J Clin Microbiol. 1983 Apr;2(2):135-40. doi: 10.1007/BF02001579.
A prospective study of post-transfusion hepatitis was conducted in 97 adult patients undergoing open heart surgery. Twelve patients developed presumed non-A, non-B hepatitis (five of these were hospitalized and three were jaundiced), and all 12 had received clotting factors from pooled plasma (fibrinogen, factor VIII, factor IX complex) from different manufacturers. Of the remaining 85 patients none received these high risk plasma derivatives and none developed hepatitis. Multiple peak ALT elevation seems to be an indication of development of chronic non-A, non-B hepatitis. In addition to the 12 cases of presumed non-A, non-B hepatitis, nine cases of serological changes related to hepatitis B virus were observed as follows: six early booster reactions of anti-HBs, but not anti-HBc, in anti-HBs and anti-HBc positive persons; one late immunization-like response for anti-HBs and two serological hepatitis B infections without transaminase elevation. Five of the nine cases were also associated with the administration of pooled clotting factors.
对97例接受心脏直视手术的成年患者进行了一项关于输血后肝炎的前瞻性研究。12例患者发生了疑似非甲非乙型肝炎（其中5例住院，3例出现黄疸），所有12例均接受了来自不同厂家的混合血浆（纤维蛋白原、凝血因子VIII、凝血因子IX复合物）中的凝血因子。其余85例患者均未接受这些高风险的血浆衍生物，也均未发生肝炎。多次ALT峰值升高似乎是慢性非甲非乙型肝炎发生的一个指标。除了12例疑似非甲非乙型肝炎病例外，还观察到9例与乙型肝炎病毒相关的血清学变化，如下：6例抗-HBs和抗-HBc阳性者出现抗-HBs早期增强反应，但抗-HBc无反应；1例抗-HBs出现晚期免疫样反应，2例血清学乙型肝炎感染但转氨酶未升高。9例中有5例也与混合凝血因子的使用有关。
