Nadler L M, Anderson K C, Marti G, Bates M, Park E, Daley J F, Schlossman S F
J Immunol. 1983 Jul;131(1):244-50.
The characterization of a new B cell-specific antigen (B4) is described in this report. With the use of a monoclonal antibody to B4, it was shown that B4 is present on B cells isolated from peripheral blood and lymphoid organs, on cell lines derived from normal and malignant B cells, and on tumor cells isolated from patients with B cell-derived neoplasms. B4, in contrast, was not detected on normal, activated, or malignant cells of T or myeloid origin. The B4 antigen is distinct from known B cell antigens, including sIg, Ia, B1, B2, Fc, and C3. Examination of mitogen-stimulated B lymphocytes suggests that the B4 antigen initially increases with B cell activation and then is lost at the terminal stage of B cell differentiation. Moreover, the observation that B4 is expressed on almost all early B cell tumors suggests that it may precede B1, CALLA, cytoplasmic mu, and B2 in early B cell ontogeny.
本报告描述了一种新的B细胞特异性抗原（B4）的特征。使用针对B4的单克隆抗体表明，B4存在于从外周血和淋巴器官分离的B细胞上、存在于源自正常和恶性B细胞的细胞系上以及存在于从B细胞源性肿瘤患者分离的肿瘤细胞上。相比之下，在T或髓系来源的正常、活化或恶性细胞上未检测到B4。B4抗原与已知的B细胞抗原不同，包括表面免疫球蛋白（sIg）、Ia、B1、B2、Fc和C3。对有丝分裂原刺激的B淋巴细胞的检测表明，B4抗原最初随着B细胞活化而增加，然后在B细胞分化的终末阶段消失。此外，几乎所有早期B细胞肿瘤都表达B4这一观察结果表明，在早期B细胞个体发生中，它可能先于B1、普通急性淋巴细胞白血病抗原（CALLA）、细胞质μ链和B2出现。
