Becker H C, Flaherty C F
Psychopharmacology (Berl). 1983;80(1):35-7. doi: 10.1007/BF00427491.
Negative contrast that occurs when rats are shifted from 32% to 4% sucrose has been shown to be reduced by chlordiazepoxide (CDP) and ethanol (ETOH). In a previous experiment, doses of 0.75 and 1.0 g/kg ETOH substantially reduced contrast while doses of 0.25 and 0.5 g/kg ETOH were much less effective. In this study, doses of 6 and 8 mg/kg CDP were shown to attenuate the negative contrast effect while smaller doses (2 and 4 mg/kg) influenced contrast to a lesser degree. Evidence for an additive effect of CDP and ETOH on contrast reduction was obtained when 4 mg/kg CDP and 0.5 g/kg ETOH were administered together.
当大鼠从32%蔗糖溶液转换到4%蔗糖溶液时出现的负性对比，已被证明可被氯氮卓（CDP）和乙醇（ETOH）降低。在先前的一项实验中，0.75克/千克和1.0克/千克的ETOH剂量可大幅降低对比，而0.25克/千克和0.5克/千克的ETOH剂量效果则要差得多。在本研究中，6毫克/千克和8毫克/千克的CDP剂量可减弱负性对比效应，而较小剂量（2毫克/千克和4毫克/千克）对对比的影响程度较小。当同时给予4毫克/千克的CDP和0.5克/千克的ETOH时，获得了CDP和ETOH对降低对比的相加效应的证据。
