Becker H C, Flaherty C F
Psychopharmacology (Berl). 1982;77(3):253-8. doi: 10.1007/BF00464576.
Negative contrast that occurs when rats are shifted from 32% to 4% sucrose was reduced by IP injections of ethanol (1.0 g/kg) on postshift day 2, but not on postshift day 1. Smaller doses (0.25 and 0.5 g/kg) were ineffective, while larger doses (1.5 and 2 g/kg) produced sedation. A dose of 0.75 g/kg had effects similar to the 1.0 g/kg dose when administered on post-shift day 2. These results parallel those obtained with chlordiazepoxide and differ somewhat from amobarbital treatment.
当大鼠从32%蔗糖溶液转换至4%蔗糖溶液时出现的负性对比,在转换后第2天腹腔注射乙醇(1.0 g/kg)可使其降低,但在转换后第1天则无此效果。较小剂量(0.25和0.5 g/kg)无效,而较大剂量(1.5和2 g/kg)会产生镇静作用。在转换后第2天给予0.75 g/kg剂量时,其效果与1.0 g/kg剂量相似。这些结果与使用氯氮卓时获得的结果相似,与使用异戊巴比妥治疗的结果略有不同。