Ferrari F, Baggio G
Psychopharmacology (Berl). 1982;78(4):326-30. doi: 10.1007/BF00433735.
The influence of lisuride on naloxone-induced withdrawal signs (wet shakes, escape attempts) was studied in morphine-dependent rats. Lisuride, injected IP at doses of 12.5 and 25 micrograms/kg, inhibited wet shakes while not significantly altering escape attempts induced by naloxone (4 mg/kg IP). At higher doses (50 and 100 micrograms/kg IP), lisuride's inhibitory effect on wet shakes persisted while escape attempts were actually potentiated with respect to control withdrawal rats. Increases in aggressive behavior were seen at all doses, and were dose-related. Haloperidol (0.3 mg/kg IP), administered 40 min before lisuride, did not modify the antagonistic effect on wet shakes, unlike sulpiride (40 mg/kg IP 30 min before lisuride), but at the same time blocked the increase in escape attempts and aggressiveness induced by lisuride. We suggest that lisuride modulates withdrawal signs by stimulation of dopamine receptors in the CNS. The effect of the dopamine mimetic N-n-propylnorapomorphine (NPA) on the same variables is reported as well as the influence of haloperidol on NPA, and a comparison between the effects of the two drugs is made.
在吗啡依赖大鼠中研究了利苏瑞得对纳洛酮诱发的戒断症状（湿抖、逃避企图）的影响。以12.5和25微克/千克的剂量腹腔注射利苏瑞得，可抑制湿抖，而对纳洛酮（4毫克/千克腹腔注射）诱发的逃避企图无明显改变。在较高剂量（50和100微克/千克腹腔注射）时，利苏瑞得对湿抖的抑制作用持续存在，而与对照戒断大鼠相比，逃避企图实际上增强了。在所有剂量下均观察到攻击行为增加，且与剂量相关。在利苏瑞得给药前40分钟给予氟哌啶醇（0.3毫克/千克腹腔注射），与舒必利（利苏瑞得给药前30分钟40毫克/千克腹腔注射）不同，并未改变对湿抖的拮抗作用，但同时阻断了利苏瑞得诱发的逃避企图增加和攻击行为。我们认为利苏瑞得通过刺激中枢神经系统中的多巴胺受体来调节戒断症状。还报告了多巴胺模拟物N-正丙基去甲阿朴吗啡（NPA）对相同变量的影响以及氟哌啶醇对NPA的影响，并对两种药物的作用进行了比较。
