Brandstätter G, Schinzel S, Wurzer H
University Clinic, Graz, Austria.
Dig Dis Sci. 1996 Sep;41(9):1814-8. doi: 10.1007/BF02088751.
The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg; N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdominal pain. Basal sphincter pressure and sphincter motility were measured for a 5-min period after treatment by endoscopic manometry. Nitroglycerin and dipyrone both caused a significant fall in basal sphincter pressure, while N-butylscopolamine and nitroglycerin produced a significant decrease in contraction frequency. Therefore, dipyrone, in contrast to tramadol and indomethacin, exhibits spasmolytic activity in addition to analgesia in biliary pain.
在一项针对36名因上腹部疼痛住院患者的单盲研究中，评估了静脉注射2.5克安乃近、50毫克曲马多、75毫克吲哚美辛、20毫克丁溴东莨菪碱和1毫克硝酸甘油对奥狄括约肌的影响，并与生理盐水进行了比较。治疗后，通过内镜测压法测量5分钟内的基础括约肌压力和括约肌运动。硝酸甘油和安乃近均使基础括约肌压力显著下降，而丁溴东莨菪碱和硝酸甘油使收缩频率显著降低。因此，与曲马多和吲哚美辛不同，安乃近在胆绞痛中除了具有镇痛作用外，还表现出解痉活性。
