Peterson J E
Aust J Exp Biol Med Sci. 1983 Feb;61(Pt 1):105-15. doi: 10.1038/icb.1983.10.
The effect of phomopsin, the mycotoxin of Phomopsis leptostromiformis responsible for lupinosis, was examined in pregnant rats and their embryos. A single injection of the rate of 0.025-0.4 mg/kg was administered on days 6, 8, 10, 12 or 14 of pregnancy or repeated injections at the daily rate of 0.03 or 0.09 mg/kg were given on days 6-10 or 11-15. Effects on embryonic development were examined on day 20. A single dose of 0.4 mg/kg or repeated doses of 0.09 mg/kg caused heavy embryonic mortality. Repeated doses of 0.03 mg/kg over days 6-10 caused a lower mortality. Foetuses that survived the higher dose rates were severely retarded in their growth and skeletal ossification was irregular. The incidence of other developmental defects was too low for phomopsin to be unequivocally implicated. The dose levels used induced lesions of lupinosis of varying severity in the dams. Toxicity for dams and embryos was greater when the total dose was administered over 5 days than after a single injection.
研究了引起羽扇豆中毒的拟茎点霉的霉菌毒素——拟茎点霉毒素对怀孕大鼠及其胚胎的影响。在怀孕第6、8、10、12或14天，以0.025 - 0.4毫克/千克的剂量单次注射，或者在第6 - 10天或11 - 15天以每天0.03或0.09毫克/千克的剂量重复注射。在第20天检查对胚胎发育的影响。单次剂量0.4毫克/千克或重复剂量0.09毫克/千克导致胚胎大量死亡。在第6 - 10天重复给予0.03毫克/千克剂量导致较低的死亡率。在较高剂量率下存活的胎儿生长严重迟缓，骨骼骨化不规则。其他发育缺陷的发生率过低，无法明确表明拟茎点霉毒素与之有关。所用剂量水平在母鼠中诱发了不同严重程度的羽扇豆中毒损伤。当总剂量在5天内给予时，对母鼠和胚胎的毒性比单次注射后更大。
