McKay L F, Brydon W G, Eastwood M A, Housley E
Atherosclerosis. 1983 Apr;47(1):77-81. doi: 10.1016/0021-9150(83)90074-6.
Methane is produced by anaerobic bacterial metabolism in the colon and is excreted in the breath of only a proportion of healthy adults. Factors influencing methane excretion have still to be elucidated. The colonic vascular circulation may influence the intestinal environment facilitating growth of methanogens. The incidence of breath methane excretion has been investigated in patients with peripheral vascular disease and a control patient group. The proportions of subjects excreting methane in the control hospital group (43%) and in patients with predominantly femoro-popliteal disease (30%) were significantly less than in patients with predominantly aorto-iliac disease (83%) (P less than 0.005 and P less than 0.001, respectively). The presence of abdominal aortic arterial disease appears to be associated with a high incidence of methane excretion.
甲烷由结肠中的厌氧细菌代谢产生，仅在一部分健康成年人的呼吸中排出。影响甲烷排泄的因素仍有待阐明。结肠血管循环可能会影响肠道环境，促进产甲烷菌的生长。已对外周血管疾病患者和对照组患者进行了呼出气甲烷排泄发生率的研究。对照组医院患者（43%）和主要患有股腘动脉疾病的患者（30%）中呼出甲烷的受试者比例显著低于主要患有主-髂动脉疾病的患者（83%）（分别为P<0.005和P<0.001）。腹主动脉疾病的存在似乎与甲烷排泄的高发生率有关。
