Peled Y, Weinberg D, Hallak A, Gilat T
Dig Dis Sci. 1987 Mar;32(3):267-71. doi: 10.1007/BF01297052.
Breath methane was studied in 394 subjects. Among 152 controls, 50.0% produced methane--42.1% of males and 57.9% of females. One hundred sixteen patients with gastrointestinal diseases were studied. Among 32 with Crohn's disease, only 2 (6.1%) produced methane, as well as 16 of 51 ulcerative colitis patients (31.4%) and 11 of 32 patients with the irritable bowel syndrome (34.4%). Breath methane is thus unusual in Crohn's disease. After bowel cleansing for colonoscopy or surgery, 15 of 18 methane producers became nonproducers, whereas after antibiotic treatment, 24 of 30 producers sustained their methane-producing status. After gentamycin and cephazolin therapy, methane production was abolished in three of eight patients. Slight spontaneous variations in methane production were also noticed with two of 23 control subjects, becoming nonproducers on restudy after 10-25 months. Thus gastrointestinal diseases, bowel cleansing and, to a much lesser degree, antibiotic therapy, affect methane production.
对394名受试者进行了呼出气甲烷研究。在152名对照者中，50.0%产生甲烷，其中男性为42.1%，女性为57.9%。对116名胃肠道疾病患者进行了研究。在32名克罗恩病患者中，只有2名（6.1%）产生甲烷，51名溃疡性结肠炎患者中有16名（31.4%）产生甲烷，32名肠易激综合征患者中有11名（34.4%）产生甲烷。因此，呼出气甲烷在克罗恩病中不常见。在进行结肠镜检查或手术的肠道清洁后，18名甲烷产生者中有15名不再产生甲烷，而在抗生素治疗后，30名产生者中有24名维持其甲烷产生状态。在庆大霉素和头孢唑林治疗后，8名患者中有3名甲烷产生消失。在23名对照者中，有2名也出现了甲烷产生的轻微自发变化，在10 - 25个月后的再次研究中不再产生甲烷。因此，胃肠道疾病、肠道清洁以及在较小程度上抗生素治疗都会影响甲烷产生。
