Delitala G, Grossman A, Besser G M
Clin Endocrinol (Oxf). 1983 Apr;18(4):401-5. doi: 10.1111/j.1365-2265.1983.tb00585.x.
Opiate peptides are known to elevate circulating GH in man, and data in other animals suggest that acetylcholine may be involved. We have administered the long-acting met-enkephalin analogue DAMME to 6 normal males, and have shown that the resulting elevation in GH is blocked by the specific cholinergic antagonist, pirenzepine. It seems likely that a cholinergic mechanism may interact with opiate-induced changes in GH in man.
已知阿片肽可提高人体循环中的生长激素水平，其他动物的数据表明乙酰胆碱可能与之有关。我们给6名正常男性注射了长效甲硫氨酸脑啡肽类似物DAMME，并发现生长激素的升高被特异性胆碱能拮抗剂哌仑西平所阻断。胆碱能机制似乎可能与人中阿片类药物诱导的生长激素变化相互作用。
