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黑腹果蝇乙醇脱氢酶基因座的核苷酸多态性

Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster.

作者信息

Kreitman M

出版信息

Nature. 1983;304(5925):412-7. doi: 10.1038/304412a0.

DOI:10.1038/304412a0
PMID:6410283
Abstract

The sequencing of eleven cloned Drosophila melanogaster alcohol dehydrogenase (Adh) genes from five natural populations has revealed a large number of previously hidden polymorphisms. Only one of the 43 polymorphisms results in an amino acid change, the one responsible for the two electrophoretic variants (fast, Adh-f, and slow, Adh-s) found in nearly all natural populations. The implication is that most amino acid changes in Adh would be selectively deleterious.

摘要

对来自五个自然种群的11个克隆的黑腹果蝇乙醇脱氢酶（Adh）基因进行测序，揭示了大量以前隐藏的多态性。43个多态性中只有一个导致氨基酸变化，即几乎在所有自然种群中都发现的两种电泳变体（快速型，Adh-f，和慢速型，Adh-s）的原因。这意味着Adh中的大多数氨基酸变化在选择上是有害的。

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Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster.黑腹果蝇乙醇脱氢酶基因座的核苷酸多态性
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