Garris D R, Billiar R B, Takaoka Y, White R, Little B
Neurosci Lett. 1983 Jun 16;37(2):149-54. doi: 10.1016/0304-3940(83)90145-3.
Progesterone- and estradiol-concentrating neurons were autoradiographically localized in the in situ, vascularly isolated, rhesus monkey hypothalamus. Estradiol-concentrating neurons were dispersed throughout the hypothalamus, their density being greatest in the medial preoptic (MPOA) and medial basal hypothalamic nuclei (viz. dorsomedial, ventromedial (VMH) and infundibular nuclei). In contrast, progesterone-concentrating neurons were less densely localized in the medial preoptic, ventromedial (medial division) and infundibular nuclei. There was a virtual absence of progestin-concentrating cells in the anterior and posterior hypothalamic zones. This localization of cells was not attributed to the perfusion pattern of the isolated hypothalamus since a complete distribution of injected microspheres was found throughout the hypothalamus. The results of these studies indicate that a possible division between estradiol- and progesterone-concentrating neurons exists within the MPOA-medial basal hypothalamic nuclei of the rhesus monkey.
通过放射自显影法，在原位、血管分离的恒河猴下丘脑中定位了集中孕酮和雌二醇的神经元。集中雌二醇的神经元分散在下丘脑各处，在内侧视前区（MPOA）和下丘脑内侧基底部核团（即背内侧、腹内侧（VMH）和漏斗核）中密度最大。相比之下，集中孕酮的神经元在内侧视前区、腹内侧（内侧部）和漏斗核中的定位密度较低。下丘脑前区和后区几乎没有集中孕激素的细胞。细胞的这种定位并非归因于分离下丘脑的灌注模式，因为在整个下丘脑中发现了注射微球的完整分布。这些研究结果表明，在恒河猴的MPOA-下丘脑内侧基底部核团内，集中雌二醇和孕酮的神经元之间可能存在区分。
