Pericić D, Manev H
Psychopharmacology (Berl). 1983;80(2):171-3. doi: 10.1007/BF00427963.
The study was undertaken to test further whether diminished GABAergic transmission might be responsible for the increased susceptibility of rats to picrotoxin-induced convulsions. In rats kept individually in cages in a noise-free room, the time between the intraperitoneal injection of the convulsant agent and the onset of convulsions was measured. Acute and subacute treatment with low doses of dihydroergotoxine (0.01-1.0 mg/kg) increased the occurrence and decreased the latency of picrotoxin-induced convulsions. Acute administration of dihydroergotoxine, 1.0 mg/kg, caused convulsions in animals injected with the subconvulsive dose (3 mg/kg) of bicuculline and of 10.0 mg/kg dihydroergotoxine in animals injected with the subconvulsive dose (1.5 mg/kg) of strychnine. Some of the animals injected with the 100% convulsive dose of strychnine were protected by dihydroergotoxine pretreatment (1.0 mg/kg) as evidenced by the lower occurrence of convulsions and fewer animals dying, as well as by a delay in the appearance of convulsions at 10.0 mg/kg. These results together with the previous findings on the GABA system suggest that dihydroergotoxine potentiates the appearance of picrotoxin and bicuculline-induced convulsions by a diminution of GABAergic transmission.
本研究旨在进一步测试GABA能传递减弱是否可能是大鼠对印防己毒素诱导惊厥易感性增加的原因。在无噪音房间单独饲养于笼中的大鼠中，测量腹腔注射惊厥剂与惊厥发作之间的时间。低剂量双氢麦角毒碱（0.01 - 1.0毫克/千克）的急性和亚急性治疗增加了印防己毒素诱导惊厥的发生率并缩短了潜伏期。双氢麦角毒碱1.0毫克/千克的急性给药在注射次惊厥剂量（3毫克/千克）荷包牡丹碱的动物中引起惊厥，在注射次惊厥剂量（1.5毫克/千克）士的宁的动物中，10.0毫克/千克双氢麦角毒碱引起惊厥。一些注射100%惊厥剂量士的宁的动物通过双氢麦角毒碱预处理（1.0毫克/千克）得到保护，表现为惊厥发生率降低、死亡动物减少，以及10.0毫克/千克时惊厥出现延迟。这些结果与先前关于GABA系统的研究结果一起表明，双氢麦角毒碱通过减弱GABA能传递增强了印防己毒素和荷包牡丹碱诱导惊厥的出现。
