Pericić D, Manev H, Levanat S, Jernej B, Vujić D, Djordjević N
Psychopharmacology (Berl). 1986;90(1):112-8. doi: 10.1007/BF00172881.
Acute (50.0 mg/kg) and repeated (0.1-10.0 mg/kg) administration of dihydroergosine (DHESN) to rats over 5 days lowered the concentration of 5-HIAA in the brain. DHESN given acutely increased the brain 5-HT in p-CPA-treated animals and diminished the probenecid-induced increase in brain 5-HIAA. In pargyline-treated rats DHESN enhanced the 5-HT/5-HIAA ratio. DHESN administered to rats repeatedly over 5 days decreased the level of 5-HT in blood platelets, and in vitro at concentrations of 10(-4) M and 10(-3) M inhibited the uptake of [14C]-5-HT in platelets. DHESN (10.0-100.0 mg/kg) potentiated the 5-HT syndrome produced in rats by pargyline and 5-HTP. This potentiation was blocked with cyproheptadine but not with haloperidol. DHESN (1.0 and 10.0 mg/kg) lowered the locomotor activity of rats and 10.0 mg/kg DHESN also reduced the duration of immobility in rats forced to swim in a restricted space. The results indicate that DHESN, like antidepressants, decreases the turnover of serotonin in the brain and potentiates the 5-HT-mediated behaviour. This might suggest that the drug should be further investigated for its potential antidepressive properties.
对大鼠急性（50.0毫克/千克）和重复（0.1 - 10.0毫克/千克）给药二氢麦角隐亭（DHESN）5天，可降低大脑中5 - 羟吲哚乙酸（5 - HIAA）的浓度。急性给予DHESN可增加对氯苯丙氨酸（p - CPA）处理动物大脑中的5 - 羟色胺（5 - HT），并减少丙磺舒诱导的大脑5 - HIAA增加。在帕吉林处理的大鼠中，DHESN提高了5 - HT/5 - HIAA比值。对大鼠重复给药5天的DHESN可降低血小板中5 - HT的水平，且在体外浓度为10^(-4) M和10^(-3) M时可抑制血小板对[14C] - 5 - HT的摄取。DHESN（10.0 - 100.0毫克/千克）增强了帕吉林和5 - 羟色氨酸（5 - HTP）在大鼠中产生的5 - HT综合征。这种增强作用被赛庚啶阻断，但未被氟哌啶醇阻断。DHESN（1.0和10.0毫克/千克）降低了大鼠的运动活性，10.0毫克/千克的DHESN还减少了被迫在有限空间游泳的大鼠的不动时间。结果表明，DHESN与抗抑郁药一样，可降低大脑中血清素的周转率并增强5 - HT介导的行为。这可能表明该药物应进一步研究其潜在的抗抑郁特性。
