Gado M, Hughes C P, Danziger W, Chi D
AJNR Am J Neuroradiol. 1983 May-Jun;4(3):699-702.
Studies involving linear measurements of ventricular size and a volumetric measurement of the cerebrospinal fluid (CSF) space were performed on elderly subjects with mild dementia of the Alzheimer type and on age-matched controls. Forty-five subjects were studied twice at a 1 year interval; linear ventricular measurements showed not only a greater degree but a more rapid evolution of brain atrophy in individuals with mild dementia as compared with controls. An additional 12 normal subjects were studied twice over a 1 year period with volumetric estimates of the CSF space, which demonstrated development of significant brain atrophy within 1 year, while linear measurements on the same scans showed no significant change. The volumetric method is regarded as a more sensitive indicator of brain volume and is potentially useful in further studies in dementia.
对患有阿尔茨海默型轻度痴呆的老年受试者以及年龄匹配的对照组进行了涉及心室大小线性测量和脑脊液（CSF）空间容积测量的研究。45名受试者每隔1年进行两次研究；线性心室测量结果显示，与对照组相比，轻度痴呆患者不仅脑萎缩程度更大，而且脑萎缩进展更快。另外12名正常受试者在1年时间内进行了两次研究，对脑脊液空间进行了容积估计，结果表明在1年内出现了明显的脑萎缩，而同一扫描的线性测量结果未显示出明显变化。容积测量法被认为是脑容量更敏感的指标，在痴呆症的进一步研究中可能有用。
