Gado M, Patel J, Hughes C P, Danziger W, Berg L
AJNR Am J Neuroradiol. 1983 May-Jun;4(3):499-500.
In order to further investigate the relationships of brain atrophy, age, and dementia, computed tomographic (CT) scans on two groups of subjects aged 65-80 years were rank-ordered according to ventricular and sulcal size. Each group contained subjects with mild senile dementia of the Alzheimer type (SDAT) and matched controls. In both experiments there was a strong correlation between these rank orders, ventricular size, and the clinical dementia rating. There was also a weaker but significant correlation between rank ordering and sulcal size. This suggests that brain atrophy in excess of that normal for age alone occurs in early SDAT.
为了进一步研究脑萎缩、年龄和痴呆之间的关系，对两组65至80岁受试者的计算机断层扫描（CT）图像，根据脑室和脑沟大小进行了排序。每组都包含患有轻度阿尔茨海默型老年痴呆症（SDAT）的受试者和匹配的对照组。在两个实验中，这些排序、脑室大小与临床痴呆评定之间均存在强相关性。排序与脑沟大小之间也存在较弱但显著的相关性。这表明，在早期SDAT中就出现了超出仅因年龄增长而导致的正常范围的脑萎缩。
