Laschinger C, Gauthier D, Valet J P, Naylor D H
Vox Sang. 1984;47(1):60-7. doi: 10.1111/j.1423-0410.1984.tb01562.x.
Monitoring of donors with selective IgA deficiency, i.e., with less than 0.5 mg IgA/l, led to the observation that serum IgA levels wer not constant. Small but significant fluctuations in IgA levels were noted (coefficient of variance: 143%) which were greater than the variability inherent in the testing methodology (coefficient of variance: 10%). These fluctuations created difficulties in terms of defining IgA-deficient blood products and had implications with respect to the mechanisms involved in IgA deficiency. With respect to supplying IgA-deficient blood products, in our experience a cutoff level of 0.5 mg/l should be the maximum permissible IgA concentration in order to ensure that no adverse reactions occur in individuals with class-specific anti-IgA.
对选择性IgA缺乏（即IgA水平低于0.5mg/l）的献血者进行监测后发现，血清IgA水平并不恒定。IgA水平出现了虽小但显著的波动（变异系数：143%），其大于检测方法本身固有的变异性（变异系数：10%）。这些波动给定义IgA缺乏的血液制品带来了困难，并且对IgA缺乏所涉及的机制有影响。关于提供IgA缺乏的血液制品，根据我们的经验，0.5mg/l的临界值应是允许的最大IgA浓度，以确保在具有类特异性抗IgA的个体中不发生不良反应。
