Tomson T, Lindbom U, Sundqvist A, Berg A
Department of Neurology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
Eur J Clin Pharmacol. 1995;48(3-4):305-8. doi: 10.1007/BF00198317.
Red cell folate concentrations were determined in 74 epileptic women in early pregnancy in a prospective study. All patients were treated continuously with antiepileptic drugs since before conception. The most frequently used drugs were carbamazepine (n = 39) and phenytoin (n = 26). Sixty-four patients (86%) were on monotherapy. Blood samples for red cell folate and antiepileptic drug concentrations were drawn before folate supplementation. Red cell folate levels in patients, 468 nmol.l-1, did not differ from those in non-epileptic, drug-free, pregnant women, 416 nmol.l-1 or from those in non-pregnant age-matched healthy controls, 412 nmol.l-1. No correlation was found between red cell folate concentrations and doses or plasma levels of phenytoin or carbamazepine.
在一项前瞻性研究中，测定了74名孕早期癫痫女性的红细胞叶酸浓度。所有患者自受孕前就持续接受抗癫痫药物治疗。最常用的药物是卡马西平（n = 39）和苯妥英（n = 26）。64名患者（86%）接受单一疗法。在补充叶酸之前采集了用于检测红细胞叶酸和抗癫痫药物浓度的血样。患者的红细胞叶酸水平为468 nmol·l-1，与未患癫痫、未服用药物的孕妇（416 nmol·l-1）或年龄匹配的未孕健康对照者（412 nmol·l-1）的水平无差异。未发现红细胞叶酸浓度与苯妥英或卡马西平的剂量或血浆水平之间存在相关性。
