Pequignot J M, Hellström S
Virchows Arch A Pathol Anat Histopathol. 1983;400(3):235-43. doi: 10.1007/BF00612185.
Intact and sympathectomized carotid bodies from rats exposed to hypoxia (room-air mixed with N2 to a final oxygen concentration of 10%) for 1, 2 and 3 weeks were analyzed by morphometric methods using the light microscope. Exposure to hypoxia enlarges the carotid bodies, in which the vascularity increases dramatically from the first week. This changed vascularity seems to be due to enhanced vasodilatation. In addition, there is a pronounced profileration of the endothelial tissue, thus suggesting an ingrowth of new blood vessels. The volume density of glomic type I, and type II cells, decreases during hypoxia but when calculated in total volumes this entity is increased 3-fold. Sympathectomy does not modify the structural changes occurring during hypoxia when compared with carotid bodies with intact innervation. Though the primary elements in the mechanism of transduction in carotid body are unknown, a remodelling of the vascular architecture may be a method by which this chemoreceptor alters its sensitivity.
对暴露于低氧环境（将室内空气与氮气混合，使最终氧气浓度达到10%）1周、2周和3周的大鼠完整的和去交感神经的颈动脉体，使用光学显微镜通过形态测量学方法进行分析。暴露于低氧环境会使颈动脉体增大，从第一周起其血管分布就会显著增加。这种血管分布的变化似乎是由于血管舒张增强所致。此外，内皮组织有明显的增生，因此提示有新血管长入。低氧期间，I型和II型球细胞的体积密度降低，但按总体积计算，该实体增加了3倍。与具有完整神经支配的颈动脉体相比，去交感神经切除术不会改变低氧期间发生的结构变化。虽然颈动脉体转导机制中的主要因素尚不清楚，但血管结构的重塑可能是这种化学感受器改变其敏感性的一种方式。
