Weissberg P L, Weaver J, Woods K L, West M J, Beevers D G
Br Med J (Clin Res Ed). 1983 Sep 10;287(6394):709-11. doi: 10.1136/bmj.287.6394.709.
In a cross sectional study of 137 women of childbearing age (16-40) the effects of normal pregnancy, hypertensive pregnancy, and oral contraceptives on red cell electrolyte content and sodium efflux rates were examined and the results compared with values in a control group of normotensive, non-pregnant women. Efflux rate constants were significantly increased in normotensive pregnancy and in women taking oral contraceptives. This was associated with a significant increase in sodium permeability in the contraceptive group. A much larger increase in sodium permeability and efflux rate constant was seen in the hypertensive group. The results permit a hypothesis that the hormonal changes induced by pregnancy and oral contraceptives increase membrane permeability to sodium and stimulate sodium efflux. The rise in blood pressure associated with use of oral contraceptives may have a similar aetiology to that occurring in pregnancy induced hypertension.
在一项针对137名育龄妇女（16 - 40岁）的横断面研究中，研究了正常妊娠、妊娠高血压以及口服避孕药对红细胞电解质含量和钠流出率的影响，并将结果与血压正常的非妊娠女性对照组的值进行了比较。正常妊娠妇女和服用口服避孕药的妇女的流出速率常数显著增加。这与避孕药组中钠通透性的显著增加有关。高血压组中钠通透性和流出速率常数的增加幅度要大得多。这些结果支持这样一种假设，即妊娠和口服避孕药引起的激素变化会增加细胞膜对钠的通透性并刺激钠流出。与使用口服避孕药相关的血压升高可能与妊娠高血压的病因相似。
