Gikavyĭ V I, Mukhin E A
Farmakol Toksikol. 1983 Jul-Aug;46(4):49-54.
It has been shown in experiments on rats anesthetized with thiopental that intravenous injection of phentolamine in a dose of 10 mg/kg enlarges the microvessels of the mesoappendix, pia mater, liver and kidneys and raises the number of functioning capillaries. Administration of etiron after phentolamine stabilized AP and corrects microcirculation. The drug raises the tone of the microvessels when applied locally in a dose of 0.15 ml (1 : 5000) or intravenously in a dose of 20 mg/kg. Etiron largely produces the constriction of the distal vessels of the arterial area of the microvascular bloodstream. The diameter of the microvessels diminished to a greater degree after intravenous injection of etiron in the presence of a alpha-adrenoreceptor blockade as compared to local application. The sensitivity of the microvessels to etiron administered after phentolamine is inversely proportional to their diameter. Combined use of etiron with alpha-adrenoblockers considerably widens the possibilities of drug control of the vascular tone.
在对用硫喷妥钠麻醉的大鼠进行的实验中发现，静脉注射10毫克/千克剂量的酚妥拉明可使阑尾系膜、软脑膜、肝脏和肾脏的微血管扩张，并增加功能正常的毛细血管数量。在酚妥拉明之后给予乙磺半胱氨酸可稳定动脉血压并改善微循环。当以0.15毫升（1:5000）的剂量局部应用或以20毫克/千克的剂量静脉注射时，该药物可提高微血管的张力。乙磺半胱氨酸在很大程度上会导致微血管血流动脉区域的远端血管收缩。与局部应用相比，在存在α-肾上腺素能受体阻滞的情况下静脉注射乙磺半胱氨酸后，微血管直径减小的程度更大。酚妥拉明后给予的乙磺半胱氨酸对微血管的敏感性与其直径成反比。乙磺半胱氨酸与α-肾上腺素能阻滞剂联合使用大大拓宽了药物控制血管张力的可能性。
