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果蝇中的甲醛诱变。乙醇脱氢酶阴性突变体的分子分析。

Formaldehyde mutagenesis in Drosophila. Molecular analysis of ADH-negative mutants.

作者信息

Benyajati C, Place A R, Sofer W

出版信息

Mutat Res. 1983 Sep;111(1):1-7. doi: 10.1016/0027-5107(83)90002-7.

DOI:10.1016/0027-5107(83)90002-7
PMID:6413850
Abstract

The Adh gene from 4 formaldehyde-generated ADH-negative mutants of Drosophila melanogaster has been cloned and sequenced. All 4 mutants bear small deletions within the gene, ranging in size from 6 to 34 base pairs. 2 of the deletions lie within a 65-base pair intervening sequence and are accompanied by other aberrations. The other two are within the protein coding region of the gene. Some of these aberrations may be explained by a slipped mispairing mechanism.

摘要

已克隆并测序了来自4个果蝇甲醛生成型乙醇脱氢酶阴性突变体的乙醇脱氢酶(Adh)基因。所有4个突变体在基因内都有小的缺失,大小从6到34个碱基对不等。其中2个缺失位于一个65个碱基对的间隔序列内,并伴有其他畸变。另外两个在基因的蛋白质编码区内。其中一些畸变可能由滑动错配机制来解释。

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Formaldehyde mutagenesis in Drosophila. Molecular analysis of ADH-negative mutants.果蝇中的甲醛诱变。乙醇脱氢酶阴性突变体的分子分析。
Mutat Res. 1983 Sep;111(1):1-7. doi: 10.1016/0027-5107(83)90002-7.
2
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