Shukla R, Shukla S B
Pharmacol Res Commun. 1983 Jul;15(7):647-54. doi: 10.1016/s0031-6989(83)80036-8.
Surgical anaesthesia between planes 2-3 with alpha-chloralose in dogs induced simultaneous depression of ventilation viz., low oxygen (PaO2) tension, high carbon dioxide (PaCO2) tension and H+ion homeostasis (high base deficit). The anaesthesia on the aforesaid planes could be achieved only by doses not below 100 mg/kg. The progressive increase in the administered dose between 100 and 200 mg/kg did not alter the acid-base profile. Further increase beyond 200 mg/kg dose was followed by a steep increase in the base deficit enhancing H+ion (cH+) concentration. However, the steep fall in PaO2 accompanied by steep rise in PaCO2 was observed only when the dose was above 250 mg/kg. The findings in the present study indicated that depression of H+ion homeostasis under chloralose anaesthesia was induced by neural mechanism independent of respiratory centres.
用α-氯醛糖使犬处于2-3期外科麻醉时，会同时导致通气抑制，即低氧（PaO2）张力、高二氧化碳（PaCO2）张力和H⁺离子稳态失衡（高碱缺失）。只有使用不低于100mg/kg的剂量才能达到上述麻醉平面。在100至200mg/kg之间逐渐增加给药剂量并不会改变酸碱状况。剂量超过200mg/kg后进一步增加，碱缺失会急剧增加，H⁺离子（cH⁺）浓度升高。然而，只有当剂量高于250mg/kg时，才会观察到PaO2急剧下降并伴有PaCO2急剧上升。本研究结果表明，氯醛糖麻醉下H⁺离子稳态失衡是由独立于呼吸中枢的神经机制引起的。
