回肠末端和结肠克罗恩病患者小肠对糖的通透性异常。

Abnormal small intestinal permeability to sugars in patients with Crohn's disease of the terminal ileum and colon.

作者信息

Ukabam S O, Clamp J R, Cooper B T

出版信息

Digestion. 1983;27(2):70-4. doi: 10.1159/000198932.

DOI:10.1159/000198932

Abstract

The absorption of lactulose and mannitol in 20 patients with Crohn's disease limited to the ileum or colon was studied, and lactulose/mannitol excretion ratios were calculated. The results were compared to those from 16 normal controls and 6 patients with ulcerative colitis. The 13 patients with ileal Crohn's disease had significantly higher lactulose/mannitol excretion ratios than the controls (p less than 0.01) or ulcerative colitics (p less than 0.01). Similarly, the 7 patients with Crohn's disease limited to the colon had significantly higher excretion ratios than the controls (p less than 0.01) or ulcerative colitics (p less than 0.01). The results provide support for the concept that Crohn's disease may be more extensive than is apparent macroscopically.

摘要

对20例病变局限于回肠或结肠的克罗恩病患者的乳果糖和甘露醇吸收情况进行了研究，并计算了乳果糖/甘露醇排泄率。将结果与16名正常对照者和6例溃疡性结肠炎患者的结果进行比较。13例回肠克罗恩病患者的乳果糖/甘露醇排泄率显著高于对照组（p<0.01）或溃疡性结肠炎患者（p<0.01）。同样，7例病变局限于结肠的克罗恩病患者的排泄率也显著高于对照组（p<0.01）或溃疡性结肠炎患者（p<0.01）。这些结果支持了克罗恩病可能比肉眼可见的范围更广泛这一观点。