黑腹果蝇中睾丸特异性β-微管蛋白亚基的结构基因B2t的遗传分析。
Genetic analysis of B2t, the structural gene for a testis-specific beta-tubulin subunit in Drosophila melanogaster.
作者信息
Kemphues K J, Raff E C, Kaufman T C
出版信息
Genetics. 1983 Oct;105(2):345-56. doi: 10.1093/genetics/105.2.345.
Abstract
Genetic analysis of the B2t locus has resulted in the recovery of four recessive mutations in the B2t structural gene and a deficiency that deletes the locus. Two of the mutations were recovered as suppressors of B2tD, a dominant male sterile mutation at the locus, and two were induced on wild-type chromosomes. All four mutant genes encode beta 2-tubulin subunits that are synthesized at normal rates but do not accumulate. All mutants are completely male sterile as homozygotes.
摘要
对B2t位点的遗传分析已在B2t结构基因中发现了四个隐性突变以及一个缺失该位点的缺陷型。其中两个突变是作为B2tD（该位点的一个显性雄性不育突变）的抑制子被发现的，另外两个是在野生型染色体上诱导产生的。所有四个突变基因编码的β2 - 微管蛋白亚基以正常速率合成但不积累。所有突变体作为纯合子时均完全雄性不育。
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