Inamasu T
Toxicol Appl Pharmacol. 1983 Oct;71(1):142-52. doi: 10.1016/0041-008x(83)90053-4.
High pressure liquid chromatography and graphite tube atomizing atomic absorption spectrometry were used to quantify monomethyl arsonic acid (MMA), dimethyl arsinic acid (DMA), and inorganic arsenic (IA: arsenite plus arsenate) in the urine and feces of male and female hamsters pretreated with a single ip injection of PCB (100 mg/kg) and 4 days later given a single po dose of arsenite (10 mg As/kg). Approximately 17 to 23% and 35 to 63% of the arsenic given was eliminated in the urine and feces, respectively, during the 5 days after the administration of arsenic. Both DMA and MMA were found in the urine but only MMA was detected in the feces, as methylated metabolite. Fecal excretion of arsenic was significantly larger in female than in males. PCB influenced the metabolism of arsenic by significantly increasing the proportion of DMA excreted into the urine of female hamsters during the 5 days after the arsenic administration, but did not alter the total amount of arsenic metabolites in any group of male or female hamsters. PCB did not affect the cumulative amounts of fecal arsenic in any group, although the excretion in the PCB-treated group of females reached the maximum level 1 day earlier than in the controls. These results suggest that the metabolism of arsenic may be regulated by certain sex-relating factors which are influenced by PCB.
采用高压液相色谱法和石墨管原子化原子吸收光谱法，对经腹腔注射一次多氯联苯（100mg/kg）预处理、4天后经口给予一次亚砷酸盐（10mg As/kg）的雄性和雌性仓鼠的尿液和粪便中的一甲基胂酸（MMA）、二甲基胂酸（DMA）和无机砷（IA：亚砷酸盐加砷酸盐）进行定量分析。在给予砷后的5天内，分别约有17%至23%和35%至63%的砷经尿液和粪便排出。尿液中同时检测到DMA和MMA，但粪便中仅检测到作为甲基化代谢产物的MMA。雌性仓鼠粪便中砷的排泄量显著高于雄性。多氯联苯影响砷的代谢，通过在给予砷后的5天内显著增加雌性仓鼠尿液中DMA的排泄比例，但并未改变任何一组雄性或雌性仓鼠中砷代谢产物的总量。多氯联苯对任何一组粪便中砷的累积量均无影响，尽管经多氯联苯处理的雌性仓鼠组的排泄量比对照组提前1天达到最高水平。这些结果表明，砷的代谢可能受某些与性别相关的因素调节，而这些因素会受到多氯联苯的影响。
