肠胃外给予环氧化酶抑制剂后牛磺胆酸盐诱导的大鼠胃糜烂的增强作用。
The potentiation of taurocholate-induced rat gastric erosions following parenteral administration of cyclo-oxygenase inhibitors.
作者信息
Whittle B J
出版信息
Br J Pharmacol. 1983 Nov;80(3):545-51. doi: 10.1111/j.1476-5381.1983.tb10727.x.
Abstract
Subcutaneous administration of anti-inflammatory doses of aspirin, indomethacin, naproxen and flurbiprofen inhibited prostacyclin formation ex vivo in the luminally-perfused gastric mucosa of anaesthetized rats. These doses of anti-inflammatory compounds potentiated the formation of gastric mucosal erosions following 3 h luminal perfusion of the topical irritant, acidified sodium taurocholate (2 mM in 100 mM HCl). The increase in luminal acid-loss during gastric perfusion of acidified taurocholate was not significantly enhanced by these anti-inflammatory agents. A correlation was found between the increase in gastric erosion formation and the inhibition of mucosal prostacyclin formation ex vivo by intravenous injection of aspirin or ketoprofen during acid-taurocholate perfusion. BW755C, which failed to inhibit mucosal prostacyclin formation ex vivo, did not significantly augment acid-taurocholate induced gastric damage. The present findings support the potentiating interactions between topical irritation and inhibition of gastric cyclo-oxygenase in the genesis of the gastric lesions.
摘要
皮下注射抗炎剂量的阿司匹林、吲哚美辛、萘普生和氟比洛芬，可抑制麻醉大鼠经腔内灌注的胃黏膜中前列环素的体外生成。这些抗炎化合物的剂量在局部刺激物酸化牛磺胆酸钠（100 mM HCl 中 2 mM）经腔内灌注 3 小时后，会增强胃黏膜糜烂的形成。这些抗炎药并未显著增强酸化牛磺胆酸钠胃灌注期间腔内酸损失的增加。在酸化牛磺胆酸钠灌注期间，通过静脉注射阿司匹林或酮洛芬，发现胃糜烂形成的增加与体外黏膜前列环素生成的抑制之间存在相关性。未能在体外抑制黏膜前列环素生成的 BW755C 并未显著增强酸牛磺胆酸钠诱导的胃损伤。目前的研究结果支持局部刺激与胃环氧化酶抑制在胃损伤发生过程中的增强相互作用。
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