Turc-Carel C, Philip I, Berger M P, Philip T, Lenoir G
C R Seances Acad Sci III. 1983;296(23):1101-3.
Chromosome studies were performed on 5 Ewing sarcoma cell lines. An identical reciprocal translocation t(11; 22) (q24; q12) was found in 4 cell lines established from 3 different tumors. These results, associated with those obtained at the same time and independently from fresh tumor cells, suggest that the translocation t(11; 22)(q24; q12) may be a chromosomal marker characteristic of Ewing sarcoma cells. This translocation involves the chromosome 22 on which the H-c-sis oncogene has been located; it could be used as a new tool for exploring the role of genetic transposition in the malignant cell transformation.
对5种尤因肉瘤细胞系进行了染色体研究。在从3种不同肿瘤建立的4种细胞系中发现了相同的相互易位t(11; 22)(q24; q12)。这些结果，与同时从新鲜肿瘤细胞独立获得的结果相关，表明易位t(11; 22)(q24; q12)可能是尤因肉瘤细胞的一种染色体标志物。这种易位涉及到已定位H-c-sis癌基因的22号染色体；它可作为探索基因转座在恶性细胞转化中作用的一种新工具。
