[人胸腺上皮细胞对胸腺素（STF）分泌的体外调节]
[In vitro regulation of the secretion of thymulin (STF) by human thymic epithelial cells].
作者信息
Cohen S, Berrih S, Dardenne M, Bach J F
出版信息
C R Seances Acad Sci III. 1983;297(2):63-5.
PMID:6416632
Abstract
The presence of thymulin (formerly called Facteur Thymique Sérique, FTS) in cultured human thymic epithelial cells was studied using a monoclonal anti-thymulin antibody in an immunofluorescence technique. The percentage of thymulin-containing cells increases gradually as a function of time, from 10% at day 4 to 90% at day 14. Furthermore, this increase can be prevented by the addition of thymulin in the culture medium. These data suggest a feedback control of thymulin secretion by thymic epithelial cells.
摘要
利用单克隆抗胸腺素抗体通过免疫荧光技术研究了培养的人胸腺上皮细胞中胸腺素（以前称为胸腺血清因子，FTS）的存在情况。含胸腺素细胞的百分比随时间逐渐增加，从第4天的10%增加到第14天的90%。此外，在培养基中添加胸腺素可阻止这种增加。这些数据提示胸腺上皮细胞对胸腺素分泌存在反馈控制。
相似文献
1
[In vitro regulation of the secretion of thymulin (STF) by human thymic epithelial cells].[人胸腺上皮细胞对胸腺素（STF）分泌的体外调节]
C R Seances Acad Sci III. 1983;297(2):63-5.
2
3
4
5
Thymic hormone-containing cells. VIII. Effects of colchicine, cytochalasin B, and monensin on secretion of thymulin by cultured human thymic epithelial cells.含胸腺激素的细胞。VIII. 秋水仙碱、细胞松弛素B和莫能菌素对培养的人胸腺上皮细胞分泌胸腺素的影响。
J Histochem Cytochem. 1986 Dec;34(12):1719-23. doi: 10.1177/34.12.3782779.
6
7
Neuroendocrine control of thymic hormonal production. II. Stimulatory effects of endogenous opioids on thymulin production by cultured human and murine thymic epithelial cells.胸腺激素分泌的神经内分泌控制。II. 内源性阿片肽对培养的人及小鼠胸腺上皮细胞胸腺素分泌的刺激作用。
Life Sci. 1990;46(23):1687-97. doi: 10.1016/0024-3205(90)90384-4.
8
Production of anti-thymulin (FTS) monoclonal antibodies by immunization against human thymic epithelial cells.通过用人胸腺上皮细胞免疫制备抗胸腺素（FTS）单克隆抗体。
J Histochem Cytochem. 1984 Apr;32(4):432-8. doi: 10.1177/32.4.6200531.
9
Thymic hormone containing cells. II. Evolution of cells containing the serum thymic factor (FTS or thymulin) in normal and autoimmune mice, as revealed by anti-FTS monoclonal antibodies. Relationship with Ia bearing cells.含胸腺激素的细胞。II. 抗血清胸腺因子（FTS或胸腺生成素）单克隆抗体揭示的正常和自身免疫小鼠中含血清胸腺因子细胞的演变。与Ia阳性细胞的关系。
Clin Exp Immunol. 1983 Apr;52(1):1-6.
10
Cytotoxic T cell response and thymic hormonal dysfunction in graft-vs-host mice.
J Immunol. 1986 Mar 15;136(6):1999-2004.
引用本文的文献
1
2
3
Pattern of secretion in thymic epithelial cells: ultrastructural studies of the effect of blockage at various levels.胸腺上皮细胞的分泌模式：不同水平阻断作用的超微结构研究
Cell Tissue Res. 1987 Jul;249(1):171-8. doi: 10.1007/BF00215431.
4
Immunohistochemical studies on a human thymic epithelial cell subset defined by the anti-cytokeratin 18 monoclonal antibody.针对由抗细胞角蛋白18单克隆抗体所定义的人类胸腺上皮细胞亚群的免疫组织化学研究。
Cell Tissue Res. 1988 Oct;254(1):225-31. doi: 10.1007/BF00220038.
5
Thymoma epithelial cells secrete thymic hormone but do not express class II antigens of the major histocompatibility complex.胸腺瘤上皮细胞分泌胸腺激素，但不表达主要组织相容性复合体的II类抗原。
J Clin Invest. 1985 Sep;76(3):1140-6. doi: 10.1172/JCI112069.
Zotero 插件