NH2-terminal sequence of the alpha and beta chains of human DC-1 antigen isolated from the JY cell line. Homology with murine I-A molecules.

The DC-1 antigen has been isolated from the JY cell line (DR4, w6). The amino terminal sequences of its alpha and beta chains are both reported and are homologous to the murine I-A antigens. The JY and previously reported LB DC-1 alpha chain sequences appear to be variants of the DC alpha chains reported by other authors. The JY DC-1 beta chain sequence appears to be identical with that deduced from a beta chain cDNA clone and thus identifies this clone. The JY and LB DC-1 beta-chains are clearly different since the latter has a blocked amino terminus.