• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一种由血小板(PLT)定义的新的决定簇,在HLA区域编码,且显然独立于HLA - D和DR位点。

A new determinant, defined by PLT, coded for in the HLA region and apparently independent of the HLA-D and DR loci.

作者信息

Termijtelen A, Bradley B A, van Rood J J

出版信息

Tissue Antigens. 1980 Mar;15(3):267-74. doi: 10.1111/j.1399-0039.1980.tb00917.x.

DOI:10.1111/j.1399-0039.1980.tb00917.x
PMID:6162224
Abstract

A PLT cell was raised between a responder cell which carried the HLA-D and DR specificities Dw3, 8; DRw3, 8 and a stimulator cell which was most likely homozygous for HLA-Dw3, DRw3. The PLT cell appeared to recognize a determinant (PL3A) which was (1) different from the officially recognized HLA-D and DR determinants, (2) was associated with HLA-A1, B8, Dw3 and DRw3, and (3) segregated in three informative families with HLA. Another responder-stimulator combination could be selected to raise PLT cells which recognized the same determinant.

摘要

在一个携带HLA - D和DR特异性Dw3、8;DRw3、8的反应细胞与一个很可能是HLA - Dw3、DRw3纯合子的刺激细胞之间培养出一个PLT细胞。该PLT细胞似乎识别一种决定簇(PL3A),其具有以下特点:(1)不同于官方认可的HLA - D和DR决定簇;(2)与HLA - A1、B8、Dw3和DRw3相关联;(3)在三个信息丰富的家系中与HLA一起分离。可以选择另一种反应细胞 - 刺激细胞组合来培养识别相同决定簇的PLT细胞。

相似文献

1
A new determinant, defined by PLT, coded for in the HLA region and apparently independent of the HLA-D and DR loci.一种由血小板(PLT)定义的新的决定簇,在HLA区域编码,且显然独立于HLA - D和DR位点。
Tissue Antigens. 1980 Mar;15(3):267-74. doi: 10.1111/j.1399-0039.1980.tb00917.x.
2
The role of primary MLC of the non HLA-D/DR determinant PL3A.非HLA-D/DR决定簇PL3A的主要混合淋巴细胞培养的作用。
Tissue Antigens. 1981 Jan;17(1):57-63. doi: 10.1111/j.1399-0039.1981.tb00666.x.
3
HLA-D-DR relationships: PLT studies of HLA-D specificities associated with DR1, DR2, and DR4.HLA-D与DR的关系:对与DR1、DR2和DR4相关的HLA-D特异性进行的血小板研究。
Hum Immunol. 1981 Jul;2(4):295-304. doi: 10.1016/0198-8859(81)90031-8.
4
The genetics of PLT response. II. HLA-DRw is a major PLT-stimulating determinant.血小板反应的遗传学。II. HLA - DRw是主要的血小板刺激决定因素。
J Immunol. 1979 Jul;123(1):37-42.
5
A "new" primed lymphocyte typing (PLT) defined DP-antigen associated with a private HLA--DR antigen.一种与私有 HLA-DR 抗原相关的“新的”致敏淋巴细胞分型(PLT)定义的 DP 抗原。
Tissue Antigens. 1980 Jul;16(1):95-104. doi: 10.1111/j.1399-0039.1980.tb00292.x.
6
Anomalous mixed lymphocyte culture reactivity between HLA--A, --B, --C, --DR identical siblings.HLA-A、-B、-C、-DR 相同的同胞之间异常的混合淋巴细胞培养反应性。
Tissue Antigens. 1979 Jan;13(1):19-34. doi: 10.1111/j.1399-0039.1979.tb01133.x.
7
Intra HLA-D/DR region recombinant detected by primed lymphocyte typing (PLT).通过启动淋巴细胞分型(PLT)检测到的HLA-D/DR区域内重组。
Tissue Antigens. 1983 Aug;22(2):123-33. doi: 10.1111/j.1399-0039.1983.tb01178.x.
8
Detection of HLA-D region products by primed lymphocyte typing (PLT).通过预致敏淋巴细胞分型法(PLT)检测HLA-D区域产物。
Hum Immunol. 1981 Jul;2(4):287-94. doi: 10.1016/0198-8859(81)90030-6.
9
Restimulation properties of cloned alloactivated lymphocytes: detection of a novel type of HLA-D/DR region determinant and allelic subtypes for HLA-Dw3 using cloned reagents.克隆化的同种异体激活淋巴细胞的再刺激特性:利用克隆化试剂检测一种新型的HLA-D/DR区域决定簇及HLA-Dw3的等位基因亚型。
Hum Immunol. 1981 Jul;2(4):315-24. doi: 10.1016/0198-8859(81)90033-1.
10
Association of PLT specificity of alloreactive lymphocyte clones with HLA-DR, MB and MT determinants.同种反应性淋巴细胞克隆的血小板特异性与HLA - DR、MB和MT决定簇的关联。
Immunogenetics. 1982;16(3):209-18. doi: 10.1007/BF00343310.

引用本文的文献

1
The HLA-D system: at least two loci and four distinct phenotypic traits per haplotype. Introduction to component typing in families and population by primed lymphocyte typing.HLA - D系统:每个单倍型至少有两个基因座和四种不同的表型特征。通过预处理淋巴细胞分型介绍家族和群体中的成分分型。
Immunogenetics. 1981;13(1-2):57-84. doi: 10.1007/BF00524605.
2
T-cell clones with similar antigen specificity may be restricted by DR, MT(DC), or SB class II HLA molecules.具有相似抗原特异性的T细胞克隆可能受DR、MT(DC)或SBⅡ类HLA分子的限制。
Immunogenetics. 1984;19(5):455-60. doi: 10.1007/BF00364648.
3
Mapping SB in relation to HLA and GLO1 using cells from first-cousin marriage offspring.
利用近亲结婚后代的细胞对与人类白细胞抗原(HLA)和乙二醛酶1(GLO1)相关的SB进行定位。
Immunogenetics. 1983;18(5):503-12. doi: 10.1007/BF00364391.
4
The canine major histocompatibility complex. Supertypic specificities defined by the primed lymphocyte test (PLT).犬主要组织相容性复合体。通过致敏淋巴细胞试验(PLT)定义的超型特异性。
Immunogenetics. 1984;19(4):359-65. doi: 10.1007/BF00345410.
5
Antigen-specific HLA-restricted human T-cell lines. I. An MT3-like restriction determinant distinct from HLA-DR.抗原特异性 HLA 限制的人 T 细胞系。I. 一种不同于 HLA - DR 的 MT3 样限制决定簇。
Immunogenetics. 1984;19(1):13-26. doi: 10.1007/BF00364472.
6
Characterization of human T-lymphocyte clones (TLCs) specific for HLA-region gene products.对HLA区域基因产物具有特异性的人T淋巴细胞克隆(TLCs)的特性分析。
Immunogenetics. 1982;16(2):117-33. doi: 10.1007/BF00364399.
7
Human allospecific TLCs generated against HLA antigens associated with DR1 through DRw8. II. Population analyses and blocking studies with monoclonal antibodies.
Immunogenetics. 1986;24(5):286-97. doi: 10.1007/BF00395533.
8
Human allospecific TLCs generated against HLA antigens associated with DR1 through DRw8. I. Growth and specificity analysis.针对与DR1至DRw8相关的HLA抗原产生的人同种特异性TLC。I. 生长和特异性分析。
Immunogenetics. 1986;23(6):368-78. doi: 10.1007/BF00372669.
9
Human monoclonal antibody MP8 detects a supertypic determinant encoded by DPB alleles DPB2.1, DPB3, DPB4.2, DPB8, DPB9, DPB10, and DPB14.
Immunogenetics. 1989;30(6):502-5. doi: 10.1007/BF02421182.
10
HLA-DP and coeliac disease: family and population studies.人类白细胞抗原-DP与乳糜泻:家族及群体研究
Gut. 1990 Jun;31(6):663-7. doi: 10.1136/gut.31.6.663.