HLA - SB(DP)α基因的基因组结构与核苷酸序列
The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene.
作者信息
Lawrance S K, Das H K, Pan J, Weissman S M
出版信息
Nucleic Acids Res. 1985 Oct 25;13(20):7515-28. doi: 10.1093/nar/13.20.7515.
Abstract
We have isolated a unique fragment of the HLA-DR alpha gene and probed human genomic DNA at low stringency to search for homologous sequences. A minimum of six non-polymorphic cross-hybridizing high molecular weight fragments were found in all DNAs examined. In order to obtain molecular clones of these cross-hybridizing fragments, we constructed lambda and cosmid libraries of human DNA and screened them at low stringency with the HLA-DR alpha gene specific subclone. We have isolated clones corresponding to each of the six fragments and, in this paper, describe those which contain the gene encoding HLA-SB(DP) alpha.
摘要
我们分离出了HLA - DRα基因的一个独特片段，并在低严谨度条件下探测人类基因组DNA以寻找同源序列。在所有检测的DNA中至少发现了六个非多态性的交叉杂交高分子量片段。为了获得这些交叉杂交片段的分子克隆，我们构建了人类DNA的λ噬菌体文库和黏粒文库，并使用HLA - DRα基因特异性亚克隆在低严谨度条件下对它们进行筛选。我们已经分离出了与六个片段相对应的克隆，并且在本文中描述了那些包含编码HLA - SB(DP)α基因的克隆。
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