Miller D S, Reid R R, Cetel N S, Rebar R W, Yen S S
JAMA. 1983 Dec 2;250(21):2937-41.
We administered pulsatile low doses of gonadotropin-releasing hormone (GnRH) (1 to 5 micrograms) to patients whose anovulation was caused by relative and absolute deficiency of endogenous GnRH. Eight such patients, including one with previous pituitary stalk transection, were treated during a total of 23 cycles; pulses of GnRH were administered via a portable pump every 96 or 120 minutes. Activation of pituitary-ovarian function with orderly development of a single dominant follicle, a luteinizing hormone surge, and ovulation occurred in 20 of the 23 cycles. The other three cycles were anovulatory. All patients responded, and five (62%) of the eight conceived, for a total of seven pregnancies and four full-term deliveries of normal infants. This study demonstrates that small pulsatile doses of GnRH can activate cyclic pituitary-ovarian function in hypogonadotropin-acyclic women and induce ovulation resulting in pregnancy and live birth.
我们对因内源性促性腺激素释放激素（GnRH）相对或绝对缺乏而导致无排卵的患者给予小剂量脉冲式GnRH（1至5微克）。包括1例既往垂体柄横断患者在内的8例此类患者，在总共23个周期中接受了治疗；通过便携式泵每96或120分钟给予一次GnRH脉冲。23个周期中有20个周期出现垂体-卵巢功能激活，伴有单个优势卵泡有序发育、促黄体生成素峰及排卵。另外3个周期无排卵。所有患者均有反应，8例患者中有5例（62%）受孕，共7次妊娠，4例足月分娩出正常婴儿。本研究表明，小剂量脉冲式GnRH可激活低促性腺激素性无排卵女性的垂体-卵巢周期性功能，并诱导排卵，从而实现妊娠及活产。
