Hurley D M, Brian R J, Burger H G
Fertil Steril. 1983 Nov;40(5):575-9. doi: 10.1016/s0015-0282(16)47411-x.
Three patients with hypothalamic amenorrhea who had previously had multiple pregnancies following gonadotropin therapy were treated with subcutaneous pulsatile gonadotropin-releasing hormone (GnRH), administered by a portable pump. After treatment with lower doses in some cases, pulses of 5 to 10 micrograms were given at 90-minute intervals, resulting in ovulation on six occasions. Ovarian steroid profiles closely resembled those of normal ovulatory cycles, and spontaneous ovulation of a single ovarian follicle was consistently demonstrated by ultrasound. Singleton pregnancy was confirmed in each patient. The results imply normal operation of the ovarian-pituitary feedback loop and suggest that subcutaneous pulsatile GnRH therapy is a safe and effective means of ovulation induction in clomiphene-resistant cases of hypothalamic amenorrhea and may possibly become the preferred method of treatment.
三名下丘脑性闭经患者，此前接受促性腺激素治疗后曾多次怀孕，此次采用便携式泵皮下脉冲式注射促性腺激素释放激素（GnRH）进行治疗。在某些情况下先给予较低剂量治疗后，每隔90分钟给予5至10微克脉冲，6次诱导排卵成功。卵巢甾体激素谱与正常排卵周期的激素谱极为相似，超声检查始终显示单个卵巢卵泡自发排卵。三名患者均确诊为单胎妊娠。这些结果提示卵巢-垂体反馈回路功能正常，表明皮下脉冲式GnRH治疗是氯米芬抵抗型下丘脑性闭经患者诱导排卵的一种安全有效的方法，且可能成为首选治疗方法。
