Caruso A, Lanzone A, Fulghesu A M, Mancuso S
Cattedra di Fisiopathologia della Riproduzione Umana, University of Cagliari, Italy.
J Endocrinol Invest. 1987 Oct;10(5):513-6. doi: 10.1007/BF03348183.
Ten patients with hypothalamic amenorrhea (HA) were treated to induce ovulation with i.v. pulsatile Gn-RH. Twentysix cycles were administered with doses ranging from 2.5 (A; no. = 10) to 5 (B; no. = 13) to 10-12.5 micrograms/90 min (C; no. = 3). Ovulation rate was 80% in A, 92.3% in B and 100% in C and pregnancy rate 25% in A and 41.6% in B. Furthermore, both the onset of ovarian response and follicular growth were found to be more suitable in groups B and C with respect to group A. Estradiol pattern as well as mid-luteal progesterone plasma levels were superimposable in the different groups. It is concluded that all doses used are effective in inducing ovulation in HA patients. However, small pulsatile doses (2.5 micrograms/90 min) might constitute a critical threshold for adequate ovarian response.
10名下丘脑性闭经（HA）患者接受静脉注射脉冲式促性腺激素释放激素（Gn-RH）诱导排卵治疗。共进行了26个周期的治疗，剂量范围为2.5微克/90分钟（A组，n = 10）至5微克/90分钟（B组，n = 13）再到10 - 12.5微克/90分钟（C组，n = 3）。A组排卵率为80%，B组为92.3%，C组为100%；A组妊娠率为25%，B组为41.6%。此外，发现B组和C组在卵巢反应的开始和卵泡生长方面比A组更合适。不同组间雌二醇水平模式以及黄体中期血浆孕酮水平相似。结论是所有使用的剂量在诱导HA患者排卵方面均有效。然而，小脉冲剂量（2.5微克/90分钟）可能是卵巢充分反应的临界阈值。
