前B细胞系中的免疫球蛋白重链类别转换伴随着DNA重排。
Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement.
作者信息
Burrows P D, Beck-Engeser G B, Wabl M R
出版信息
Nature. 1983;306(5940):243-6. doi: 10.1038/306243a0.
DOI:10.1038/306243a0
PMID:6417542
Abstract
Switching of an Abelson virus-transformed mouse lymphoid cell line from immunoglobulin mu to gamma 2b heavy-chain synthesis in vitro is accompanied by loss of DNA sequences between the JH and C gamma 2b gene segments, and thus cannot be explained by differential RNA processing. The light-chain loci of both mu- and gamma 2b-producing cell clones are in the embryonic configuration, which indicates that class switching can occur in pre-B cells.
摘要
在体外，阿贝尔森病毒转化的小鼠淋巴细胞系从免疫球蛋白μ重链合成转换为γ2b重链合成的过程中，伴随有JH和Cγ2b基因片段之间DNA序列的缺失，因此无法用差异RNA加工来解释。产生μ链和γ2b链的细胞克隆的轻链基因座均处于胚胎构型，这表明类别转换可发生在前B细胞中。
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