Ziegler V E, Wylie L T, Biggs J T
J Pharm Sci. 1978 Apr;67(4):554-5. doi: 10.1002/jps.2600670431.
Nine or 10 serial steady-state plasma measurements of amitryptyline, desipramine, desmethyldoxepin, doxepin, imipramine, nortriptyline, or protriptyline were made in 23 depressed patients. Each patient was monitored for compliance by pill counts, and sampling time was controlled carefully to determine intrapatient variability of steady-state tricyclic levels on a day-to-day basis. The coefficients of variation during serial sampling of the various ingested drugs were: amitriptyline, 21%; desipramine, 26%; doxepin, 21%; imipramine, 14%; nortriptyline, 13%; and protriptyline, 17%. The therapeutic ranges for the tricyclic antidepressants are relatively wide, so coefficients of variation of these magnitudes indicate that the position of an individual patient in relation to the optimal therapeutic range can be reliably determined on a clinical basis.
对23名抑郁症患者进行了9次或10次阿米替林、去甲替林、去甲基多塞平、多塞平、丙咪嗪、去甲替林或普罗替林的连续稳态血浆测量。通过清点药片监测每位患者的依从性，并仔细控制采样时间，以确定患者体内稳态三环类药物水平的日常个体差异。各种摄入药物连续采样期间的变异系数为：阿米替林21%；去甲替林26%；多塞平21%；丙咪嗪14%；去甲替林13%；普罗替林17%。三环类抗抑郁药的治疗范围相对较宽，因此这些幅度的变异系数表明，在临床基础上可以可靠地确定个体患者相对于最佳治疗范围的位置。
